Dr. Paul Q. Trombley

207 BRF
Florida State University
Biomedical Research Facility
Tallahassee, FL 32306-4340
(850) 644-1614

Ph.D.
University of Oregon
1990

 

Electrophysiology Experiment

Associate Faculty
  Dr. Laura  Blakemore Dr. Laura Blakemore
BRF
(850) 644-1616

 
Graduate Students
  John  Corthell John Corthell
238 BRF
(850) 644-1616

  Kirill  Korshunov Kirill Korshunov
BRF 238
(850) 644-3076

  Andrea  Stathopoulos Andrea Stathopoulos
238 BRF
(850) 644-1616

Dr. Paul Q. Trombley

Associate Professor of Biology & Neuroscience

Research Interest

Synaptic physiology and synaptic modulation using patch-clamp electrophysiology from brain slices and primary neuronal culture (olfactory bulb, hippocampus). We examine neurotransmitter receptors and ion channels related to neurodegenerative conditions (e.g. Alzheimer's disease, stroke) and psychiatric disorders (e.g. depression, anxiety, schizophrenia). One model is the olfactory bulb of the mammalian brain which contains two primary population of neurons. Large neurons, mitral/tufted cells, receive signals about odors in the environment from sensory neurons in the nose. This odor information is then sent to higher brain regions for further processing. Small interneurons, granule and periglomerular cells, modify the output of mitral/tufted cells. The olfactory bulb has high concentrations of neuroactive substances implicated in a variety of neurophathological conditions. Click on the link below to see an example of an electrophysiology experiment demonstrating the activation of receptors involved in some of these conditions.

Selected Recent Publications

Corthell JT, Stathopoulos AM, Watson CC, Bertram R, Trombley PQ. Olfactory bulb monoamine concentrations vary with time of day.. Neuroscience. 247: 234-241. (2013)
Corthell JT, Fadool DA, Trombley PQ. Connexin and AMPA receptor expression changes over time in the rat olfactory bulb.. Neuroscience. 222: 38-48. (2012) Abstract
Trombley PQ, Blakemore LJ, Hill BJ. Zinc modulation of glycine receptors. Neuroscience. 186:32-8. (2011) Abstract
Davila NG, Houpt TA, Trombley PQ. Expression and function of kainate receptors in the rat olfactory bulb. Synapse. 61(5):320-34. (2007)
Blakemore LJ, Levenson CW, Trombley PQ. Neuropeptide Y modulates excitatory synaptic transmission in the olfactory bulb. Neuroscience. 138(2):663-74. (2006)
Blakemore LJ, Resasco M, Mercado MA, Trombley PQ. Evidence for Ca(2+)-permeable AMPA receptors in the olfactory bulb. Am J Physiol Cell Physiol. 290(3):C925-35. (2006)
Horning MS, Kwon B, Blakemore LJ, Spencer CM, Goltz M, Houpt TA, Trombley PQ. Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor subunit expression in rat olfactory bulb. Neurosci Lett. 372(3):230-4. (2004)
Blakemore LJ, Trombley PQ. Diverse modulation of olfactory bulb AMPA receptors by zinc. Neuroreport. 15(5):919-23. (2004)