Dr. Paul Q. Trombley is currently accepting new graduate students for Fall 2015
The primary research goal of our laboratory is to understand the cellular and molecular mechanisms that regulate neuronal excitability and the efficacy of synaptic transmission. Our experimental approach uses primary neuronal culture, brain slices, and patch-clamp electrophysiology, in combination with molecular biology and histological techniques, to examine modulation of ion channels, neurotransmitter receptors, and synaptic circuits. One of our current projects involves determining the cellular and molecular basis of circadian rhythms in the olfactory system. We are exploring how electrical synapses formed by gap junctions and rhythmic expression of monoamine neurotransmitters (norepinephrine, dopamine, serotonin, and melatonin) contribute to rhythmic regulation of synaptic circuits underlying odor information processing. Other projects include investigating the role of zinc as a neuromodulator and the function of circuits of the hippocampus, hypothalamus, and amygdala.
Selected Recent Publications
Corthell JT, Olcese J, Trombley PQ. Melatonin in the mammalian olfactory bulb.. Neuroscience. 261: 74-84. (2014)
Corthell JT, Stathopoulos AM, Watson CC, Bertram R, Trombley PQ. Olfactory bulb monoamine concentrations vary with time of day.. Neuroscience. 247: 234-241. (2013)
Blakemore LJ, Tomat E, Lippard SJ, Trombley PQ. Zinc released from olfactory bulb glomeruli by patterned electrical stimulation of the olfactory nerve.. Metallomics. 5(3):208-13. doi: 10.1039/c3mt20158a. (2013)
Corthell JT, Fadool DA, Trombley PQ
. Connexin and AMPA receptor expression changes over time in the rat olfactory bulb.
. 222: 38-48. (2012) Abstract
, Blakemore LJ, Hill BJ. Zinc modulation of glycine receptors
. 186:32-8. (2011) Abstract
Davila NG, Houpt TA, Trombley PQ. Expression and function of kainate receptors in the rat olfactory bulb. Synapse. 61(5):320-34. (2007)
Blakemore LJ, Levenson CW, Trombley PQ. Neuropeptide Y modulates excitatory synaptic transmission in the olfactory bulb. Neuroscience. 138(2):663-74. (2006)
Blakemore LJ, Resasco M, Mercado MA, Trombley PQ. Evidence for Ca(2+)-permeable AMPA receptors in the olfactory bulb. Am J Physiol Cell Physiol. 290(3):C925-35. (2006)
Horning MS, Kwon B, Blakemore LJ, Spencer CM, Goltz M, Houpt TA, Trombley PQ. Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor subunit expression in rat olfactory bulb. Neurosci Lett. 372(3):230-4. (2004)
Blakemore LJ, Trombley PQ. Diverse modulation of olfactory bulb AMPA receptors by zinc. Neuroreport. 15(5):919-23. (2004)