The Rushton Lecture Series
Fall 2009

I Think, Therefore ION
Ligand- and Voltage-gated Ion Channels
Fri -Sat, November 6 - 7

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The Ruston Lecture series is named for distinguished neuroscientist W. A. H. Rushton, formerly a regular visitor to FSU. It features Internationally prominent neuroscientists in colloquia and/or symposia. Formal and informal interactions with these internationally recognized experts are an important part of the Neuroscience Program's contribution to the academic environment at Florida State University.

The Speakers:

• Dr. Anis Contractor
  (Northwestern University, Feinberg School of Medicine)
  Using knockout mice to understand kainate receptor function in the brain
• Dr. Ray Dingledine
  (Emory University - Glutamate Receptors and Epileptogenesis)
  The glutamate receptor diaspora
• Dr. James Trimmer
  (UC Davis - Visualization, Trafficking, and Modulation of Voltage-gated K Channels)
  Regulation of neuronal ion channel expression, localization and function through multi-site phosphorylation
• Dr. Daniel Minor
  (UCSF - Voltage-gated Ion Channel Crystollography/Structure-Function)
  Structural insights into ion channel function and modulation

All questions or concerns about this series should be directed to the event's hosts and organizers, Dr. Paul Trombley and Dr. Debi Fadool.

Relevant Links:

• Misonou et al., 2004. Regulation of ion channel localization and phosphorylation by neuronal activity. Nature Neuroscience. 7(7): 711-718. PDF
• Misonou et al., 2006. Bidirectional activity-dependent regulation of neuronal ion channel phosphorylation. J. Neuroscience. 26(52):13505-12514. PDF
• Park et al., 2008. Potassium channel phosphorylation in excitable cells: Providing dynamic functional variability to a diverse family of ion channels. Physiology 23: 49-57. PDF
• Kim et al., 2008. Structures of CaV2 Ca/CaM-IQ domain complexes reveal binding modes that underlie calcium dependent inactivation and facilitation. Structure 16: 1455-1467. PDF
• Pioletti et al., 2008. Three dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross shaped octamer. Nat. Struct. Mol.Biol. 13(11):987-95 PDF
• Minor, D. 2007. The neurobiologist's guide to structural biology: A primer on why macromolecular structure matters and how to evaluate structural data. Neuron. 54: 511-533 PDF
• Mott et al., 2003. Subunit-dependent modulation of kainate receptors by extracelluar protons and polyamines. J. Neurosci. 23(4): 1179-1188. PDF
• Mott et al., 2008. pH-dependent inhibition of kainate receptors by zinc. J. Neurosci. 28(7): 1659-1671.  PDF
• Dingledine et al., 1999. The glutamate receptor ion channels. Pharm. Reviews 51(1): 1-55. PDF
• Fernandes et al., 2009. High-affinity kainate receptor subunits are necessary for ionotropic but not metabotropic signaling. Neuron 63: 818-829. PFD
• Contractor et al., 2001. Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus. Neuron. 29(1):209-216. PDF