Dr. James  Olcese

2300E MSR
Florida State University
College of Medicine
1115 West Call Street
Tallahassee, FL 32306-4300
(850) 645-1479

Marquette University

Dr. James Olcese

Associate Professor of Biomedical Sciences, Neuroscience & Molecular Biophysics

Research Interest

Circadian Physiology (biological rhythms, sleep disorders, jet lag); Neuroendocrine mechanisms (hormonal systems, reproductive function, melatonin, GnRH)

Current Projects

Dr. Olcese has served as a visiting assistant professor at Marquette University in Milwaukee, Wis., as an assistant professor and associate professor at Rhodes College in Memphis, Tenn., and as a professor and group leader at the Institute for Hormone & Fertility Research at the University of Hamburg Medical School in Hamburg, Germany.


B.S., Biology, Emory University, Atlanta, Ga.
Ph.D., Physiology, Marquette University, Milwaukee, Wis.
Postdoctoral fellow, Dept. of Anatomy, University of Mainz, Germany


Dean's Award for Outstanding Faculty Research - Rhodes College, Memphis, TN


Endocrine Society
Society for Neuroscience
Society for Research on Biological Rhythms
New York Academy of Sciences
European Biological Rhythms Society
Society of Sigma Xi

Selected Recent Publications

Olcese J, Beesley S. The Clinical Significance of Melatonin Receptors in the Human Myometrium.. Fertility and Sterility. 102: 329-335. (2014)
O'Neal-Moffitt G, Pilli J, Kumar SS, Olcese J. Genetic deletion of melatonin receptors enhances murine cognitive and motor performance.. Neuroscience. 277: 506-521. (2014)
Nair-Collins M, Northrup J, Olcese J. Hypothalamic-pituitary function in brain death: A review.. J. Intensive Care Medicine. In press. (2014)
Corthell JT, Olcese J, Trombley PQ. Melatonin in the mammalian olfactory bulb.. Neuroscience. 261: 74-84. (2014)
Olcese J, Lozier S, Paradise C. Melatonin and the timing of human parturition.. Reprod. Sci. 20: 168-174. (2012)
Dragicevic N, Copes N, O’Neal-Moffitt G, Jin J, Buzzeo R, Mamcarz M, Tan J, Cao C, Olcese JM, Arendash GW, Bradshaw PC. Melatonin treatment restores mitochondrial function in Alzheimer’s mice: A mitochondrial protective role of melatonin membrane receptor signaling.. J Pineal Res. 51:75-86. (2011)
Sharkey J, Cable C, Olcese J. Melatonin sensitizes human myometrial cells to oxytocin in a PKCα/ERK-dependent manner. J Clin Endocrinol Metabol. 95: 2902-08. (2010)
Dubocovich ML, Delagrange P, Krause DN, Sugden D, Cardinali DP, Olcese J. Nomenclature, Classification and Pharmacology of G Protein-Coupled Melatonin Receptor. Pharmacol Rev. 62(3): 343-380. (2010)
Sharkey JT, Puttaramu R, Word RA, Olcese J. Melatonin synergizes with oxytocin to enhance contractility of human myometrial smooth muscle cells. J Clin Endocrinol Metab. 94(2):421-7. (2009)
Olcese JM, Cao C, Mori T, Mamcarz MB, Maxwell A, Runfeldt MJ, Wang L, Zhang C, Lin X, Zhang G, Arendash GW. Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease. J Pineal Res. 47(1):82-96. (2009)
Resuehr HE, Resuehr D, Olcese J. Induction of mPer1 expression by GnRH in pituitary gonadotrope cells involves EGR-1. Mol Cell Endocrinol. 311(1-2):120-5. (2009)
Sharkey J, Olcese J. Transcriptional inhibition of oxytocin receptor expression in human myometrial cells by melatonin involves protein kinase C signaling. J Clin Endocrinol Metab. 92(10):4015-9. (2007)
Resuehr D, Wildemann U, Sikes H, Olcese J. E-box regulation of gonadotropin-releasing hormone (GnRH) receptor expression in immortalized gonadotrope cells. Mol Cell Endocrinol. 278(1-2):36-43. (2007)
Resuehr D, Sikes HE, Olcese J. Exploratory investigation of the effect of melatonin and caloric restriction on the temporal expression of murine hypothalamic transcripts. J Neuroendocrinol. 18(4):279-89. (2006)
Olcese J, Sikes HE, Resuehr D. Induction of PER1 mRNA expression in immortalized gonadotropes by gonadotropin-releasing hormone (GnRH): involvement of protein kinase C and MAP kinase signaling. Chronobiol Int. 23(1-2):143-50. (2006)
Resuehr D, Olcese J. Caloric restriction and melatonin substitution: effects on murine circadian parameters. Brain Res. 1048(1-2):146-52. (2005)