Dr. Zuoxin Wang
Distinguished Research Professor of Psychology & Neuroscience
- • Dr. Wang is accepting a graduate student in collaboration with Dr. Kabbaj. • Selective social attachments, such as adult male-female bonds or parent-infant attachment, are among the most powerful driving forces of human behavior and play an important role for human mental health and development. Our research has been focused on understanding the neurochemical and hormonal mechanisms underlying adult pair bonding behavior using a socially monogamous rodent species, the prairie vole (Microtus ochrogater), as a model system. We have been focusing on several neurochemical systems such as oxytocin, vasopressin, and dopamine and examining their roles and interactions in the regulation of pair bonding behavior. We have also been investigating how these neurochemical systems mediate biobehavioral responses to pair bonding disrupted by factors such as drugs of abuse or stressful experience.
- Current Research
- Receptor-specific mechanisms underlying dopamine regulation of pair bonding • Neurochemical interactions in the regulation of pair bonding behavior • Social environment and gonadal steroid regulation of adult neurogenesis in voles • Amphetamine, dopamine, and conditioned place preference in voles • Dopamine regulation of social and drug reward interactions.
- Recent Publications
Donovan M, Mackey CS, Platt GN, Rounds J, Brown AN, Trickey DJ, Liu Y, Jones KM, Wang Z (2020). Social isolation alters behavior, the gut-immune-brain axis, and neurochemical circuits in male and female prairie voles. Neurobiol Stress, 13:100278. PubMed Duclot F, Sailer L, Koutakis P, Wang Z, Kabbaj M (2020). Transcriptomic Regulations Underlying Pair-bond Formation and Maintenance in the Socially Monogamous Male and Female Prairie Vole. Biol Psychiatry, S0006-3223(20)32108-9. PubMed Jorgensen C, Wang Z (2020). Hormonal Regulation of Mammalian Adult Neurogenesis: A Multifaceted Mechanism. Biomolecules, 10(8):1151. PubMed Elvir L, Duclot F, Wang Z, Kabbaj M (2019). Epigenetic regulation of motivated behaviors by histone deacetylase inhibitors. Neurosci Biobehav Rev, 105:305-317. PubMed Liu Y, Donovan M, Jia X, Wang Z (2019). The ventromedial hypothalamic circuitry and male alloparental behaviour in a socially monogamous rodent species. Eur J Neurosci, 50(11):3689-3701. PubMed Donovan M, Liu Y, Wang Z (2018). Anxiety-like behavior and neuropeptide receptor expression in male and female prairie voles: The effects of stress and social buffering. Behav Brain Res, 70-78. PubMed Lei K, Liu Y, Smith AS, Lonstein JS, Wang Z (2017). Effects of pair bonding on parental behavior and dopamine activity in the nucleus accumbens in male prairie voles. Eur J Neurosci, 46(7):2276-2284. PubMed Tabbaa M, Lei K, Liu Y, Wang Z (2017). Paternal deprivation affects social behaviors and neurochemical systems in the offspring of socially monogamous prairie voles. Neuroscience, 284-297. PubMed Duclot F, Wang H, Youssef C, Liu Y, Wang Z, Kabbaj M (2016). Trichostatin A (TSA) facilitates formation of partner preference in male prairie voles (Microtus ochrogaster). Horm Behav, 81:68-73. PubMed Gobbrogge K, Wang Z (2016). The ties that bond: neurochemistry of attachment in voles. Curr Opin Neurobiol, 80-8. PubMed Lieberwirth C, Pan Y, Liu Y, Zhang Z, Wang Z (2016). Hippocampal adult neurogenesis: Its regulation and potential role in spatial learning and memory. Brain Res, 127-40. PubMed Lieberwirth C, Wang Z (2016). The neurology of pair bond information, bond disruption, and social buffering. Curr Opin Neurobiol, 8-13. PubMed Pan Y, Liu Y, Lieberwirth C, Zhang Z, Wang Z (2016). Species differences in behavior and cell proliferation/survival in the adult brains of female meadow and prairie voles. Neuroscience, 315:259-70. PubMed Smith AS, Tabbaa M, Lei K, Eastham P, Butler MJ, Linton L, Altshuler R, Liu Y, Wang Z (2016). Local oxytocin tempers anxiety by activating GABAA receptors in the hypothalamic paraventricular nucleus. Psychoneuroendocrinology, 63:50-8. PubMed Tabbaa M, Paedae B, Liu Y, Wang Z (2016). Neuropeptide regulation of social attachment: The prairie vole model. Compr Physiol, 7(1):81-104. PubMed Tabbaa M, Paedae B, Liu Y, Wang Z (2016). Neuropeptide Regulation of Social Attachment: The Prairie Vole Model. Compr Physiol, 7(1):81-104. PubMed