Dr. Sanjay Kumar
Professor of Biomedical Sciences & Neuroscience
- Neuronal Plasticity, Receptor Biophysics, Temporal Lobe Epilepsy.
- Current Research
- Basic research in the Kumar laboratory is focused on synaptic physiology underlying neocortical function and plasticity. We are particularly interested in understanding the workings and role of glutamatergic AMPA and N-methyl-D-aspartate Receptors in these processes. Translational research efforts of the lab are focused on deciphering basic pathophysiological mechanisms underlying Temporal Lobe Epilepsy, the most common type of epilepsy in adults. Here, we seek to identify / isolate ictogenic cells and circuits within the parahippocampal region for the purposes of developing therapeutic / interventional strategies to combat TLE. We use a variety of tools and techniques with electrophysiology being the mainstay of our research.
- Recent Publications
Beesley S, Sullenberger T, Ailani R, D'Orio C, Crockett MS, Kumar SS (2021). d-Serine Intervention In The Medial Entorhinal Area Alters TLE-Related Pathology In CA1 Hippocampus Via The Temporoammonic Pathway. Neuroscience, 453:168-186. PubMed Beesley S, Sullenberger T, Crotty K, Ailani R, D'Orio C, Evans K, Ogunkunle EO, Roper MG, Kumar SS (2020). D-serine mitigates cell loss associated with temporal lobe epilepsy. Nat Commun, 11(1):4966. PubMed Beesley S, Sullenberger T, Kumar SS (2020). The GluN3 subunit regulates ion selectivity within native N-methyl-d-aspartate receptors. IBRO Rep, 9:147-156. PubMed Beesley S, Sullenberger T, Pilli J, Abbasi S, Gunjan A, Kumar SS (2019). Colocalization of distinct NMDA receptor subtypes at excitatory synapses in the entorhinal cortex. J Neurophysiol, 121(1):238-254. PubMed Sullenberger T, Don H, Kumar SS (2019). Functional Connectivity of the Parasubiculum and Its Role in Temporal Lobe Epilepsy. Neuroscience, 410:217-238. PubMed