Florida State University
Dr. Mohamed Kabbaj is currently accepting new graduate students.

Dr. Mohamed Kabbaj

Professor of Biomedical Sciences & Neuroscience

Biomedical Sciences
MSR 3300H


The focus of our research is to understand the neurobiology underlying individual differences and sex differences in depression and drug addiction. Another focus of our research is to examine epigenetic mechanisms underlying social behaviors.
Recent Publications
Elvir L, Duclot F, Wang Z, Kabbaj M, Epigenetic regulation of motivated behaviors by histone deacetylase inhibitors, Neurosci Biobehav Rev, 2019 PubMed
Sailer L, Duclot F, Wang Z, Kabbaj M, Consequences of prenatal exposure to valproic acid in the socially monogamous prairie voles, Sci Rep, 2019 PubMed
Schoepfer KJ, Strong CE, Saland SK, Wright KN, Kabbaj M, Sex- and dose-dependent abuse liability of repeated subanesthetic ketamine in rats., Physiol Behav, 2019 PubMed
Strong CE, Wright KN, Kabbaj M, Sex and Individual Differences in Alcohol Intake Are Associated with Differences in Ketamine Self-Administration Behaviors and Nucleus Accumbens Dendritic Spine Density, eNeuro, 2019 PubMed
Wright KN, Hagarty DP, Strong CE, Schoepfer KJ, Kabbaj M, Sex-Dependent Ketamine Addiction-Like Behavior Profile Following Exposure to Chronic Mild Stress, Chronic Stress, 2019 PubMed
Dossat AM, Wright KN, Strong CE, Kabbaj M, Behavioral and biochemical sensitivity to low doses of ketamine: Influence of estrous cycle in C57BL/6 mice, Neuropharmacology, 2018 PubMed
Higgins R, Kabbaj M, Hatcher A, Wang Y, The absence of specific yeast heat-shock proteins leads to abnormal aggregation and compromised autophagic clearance of mutant Huntingtin proteins, PLoS One, 2018 PubMed
Kabbaj M, Wang Z, Neurobiology of motivated behaviors, Integr Zool, 2018 PubMed
Saland SK, Kabbaj M, Sex Differences in the Pharmacokinetics of Low-dose Ketamine in Plasma and Brain of Male and Female Rats, J Pharmacol Exp Ther, 2018 PubMed
Strong CE, Kabbaj M, On the safety of repeated ketamine infusions for the treatment of depression: Effects of sex and developmental periods, Neurobiol Stress, 2018 PubMed
Wang W, Duclot F, Groveman BR, Carrier N, Qiao H, Fang XQ, Wang H, Xin W, Jiang XH, Salter MW, Ding XS, Kabbaj M, Yu XM, Hippocampal protein kinase D1 is necessary for DHPG-induced learning and memory impairments in rats, PLoS One, 2018 PubMed
Wright KN, Dossat AM, Strong CE, Sailer LL, Pavlock SM, Kabbaj M, Optogenetic inhibition of medial prefrontal cortex projections to the nucleus accumbens core and methyl supplementation via L-Methionine attenuates cocaine-primed reinstatement, Integr Zool, 2018 PubMed
Wright KN, Kabbaj M, Sex differences in sub-anesthetic ketamine's antidepressant effects and abuse liability, Curr Opin Behav Sci, 2018 PubMed
Dossat AM, Jourdi H, Wright KN, Strong CE, Sarkar A, Kabbaj M, Viral-mediated Zif268 expression in the prefrontal cortex protects against gonadectomy-induced working memory, long-term memory, and social interaction deficits in male rats, Neuroscience, 2017 PubMed
Dossat AM, Sanchez-Gonzalez MA, Koutnik AP, Leitner S, Ruiz EL, Griffin B, Rosenberg JT, Grant SC, Fincham FD, Pinto JR, Kabbaj M, Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy, FASEB J, 2017 PubMed
Duclot F, Kabbaj M, Comparative transcriptomic analysis of the effects of antidepressant drugs in stress-susceptible mice, Biol Psychiatry , 2017 PubMed
Saland SK, Duclot F, Kabbaj M, Integrative analysis of sex differences in the rapid antidepressant effects of ketamine in preclinical models for individualized clinical outcomes, Curr Opin Behav Sci, 2017 PubMed
Strong CE, Schoepfer KJ, Dossat AM, Saland SK, Wright KN, Kabbaj M, Locomotor sensitization to intermittent ketamine administration is associated with nucleus accumbens plasticity in male and female rats, Neuropharmacology, 2017 PubMed
Sun H, Damez-Werno DM, Scobie KN, Shao NY, Dias C, Rabkin J, Wright KN, Mouzon E, Kabbaj M, Neve R, Turecki G, Shen L, Nestler EJ, Regulation of BAZ1A and nucleosome positioning in the nucleus accumbens in response to cocaine, Neuroscience, 2017 PubMed
Wright KN, Strong CE, Addonizio MN, Brownstein NC, Kabbaj M, Reinforcing properties of an intermittent, low dose of ketamine in rats: effects of sex and cycle, Psychopharmacology (Berl)., 2017 PubMed
Wright KN, Strong CE, Addonizio MN, Brownstein NC, Kabbaj M, Reinforcing properties of an intermittent, low does of ketamine in rats: effects of sex and cycle, Psychopharmacology (Berl), 2017 PubMed
Duclot F, Perez-Taboada I, Wright KN, Kabbaj M, Prediction of individual differences in fear response by novelty seeking, and disruption of contextual fear memory reconsolidation by ketamine, Neuropharmacology, 2016 PubMed
Duclot F, Wang H, Youssef C, Liu Y, Wang Z, Kabbaj M, Trichostatin A (TSA) facilitates formation of partner preference in male prairie voles (Microtus ochrogaster), Horm Behav, 2016 PubMed
Saland SK, Schoepfer KJ, Kabbaj M, Hedonic sensitivity to low-dose ketamine is modulated by gonadal hormones in a sex-dependent manner, Sci Rep, 2016 PubMed
Sarkar A, Kabbaj M, Sex Differences in Effects of Ketamine on Behavior, Spine Density, and Synaptic Proteins in Socially Isolated Rats, Biol Psychiatry, 2016 PubMed
Carrier N, Saland SK, Duclot F, He H, Mercer R, Kabbaj M, The Anxiolytic and Antidepressant-like Effects of Testosterone and Estrogen in Gonadectomized Male Rats, Biol Psychiatry, 2015 PubMed
Duclot F, Kabbaj M, The estrous cycle surpasses sex differences in regulating the transcriptome in the rat medial prefrontal cortex and reveals an underlying role of early growth response 1, Genome Biol, 2015 PubMed
Duclot F, Kabbaj M, Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants, J Exp Biol, 2015 PubMed
Fang XQ, Qiao H, Groveman BR, Feng S, Pflueger M, Xin WK, Ali MK, Lin SX, Xu J, Duclot F, Kabbaj M, Wang W, Ding XS, Santiago-Sim T, Jiang XH, Salter MW, Yu XM, Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors, Mol Brain, 2015 PubMed
Sanchez-Gonzalez MA, Guzik P, May RW, Koutnik AP, Hughes R, Muniz S, Kabbaj M, Fincham FD, Trait anxiety mimics age-related cardiovascular autonomic modulation in young adults, J Hum Hypertens, 2015 PubMed
Wright KN, Hollis F, Duclot F, Dossat AM, Strong CE, Francis TC, Mercer R, Feng J, Dietz DM, Lobo MK, Nestler EJ, Kabbaj M, Methyl supplementation attenuates cocaine-seeking behaviors and cocaine-induced c-Fos activation in a DNA methylation-dependent manner, J Neurosci, 2015 PubMed

All Publications PubMed

Lab Website

Neuro Grads and Postdocs

Alfonso Brea Guerrero, Graduate Student

Michelle Crawford, Graduate Student

Florian Duclot, Affiliate - Biomedical sciences

Devin Hagarty, Graduate Student

Jordan Logue, Graduate Student

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