Accepting new graduate students.
Dr. Jian Feng
Associate Professor of Biological Science & Neuroscience
- Epigenetic regulation of neuropsychiatric disorders.
- Current Research
- Brain function requires accurate control of gene transcription in response to environmental stimuli. Epigenetics (e.g. histone modifications, and DNA methylation) plays a core role during this process by modulating gene expression without changing underlying DNA sequences. It has therefore been implicated in various neuropsychiatric disorders, though many of the details are still unknown. With help of modern genomic tools and novel epigenetic concepts largely developed in proliferating cultured cells, I aim to decipher out the epigenetic underpinnings of neuropsychiatric diseases in vivo by using rodent models.
- Recent Publications
Chitaman JM, Fraser P, Feng J (2019). Three-dimensional chromosome architecture and drug addiction. Curr Opin Neurobiol, 137-145. PubMed Brown AN, Feng J (2017). Drug Addiction and DNA Modifications. Adv Exp Med Biol, 105-125. PubMed Hu Q, Kim EJ, Feng J, Grant GR, Heller EA (2017). Histone posttranslational modifications predict specific alternative exon subtypes in mammalian brain. PLoS Comput Biol, 13(6):e1005602. PubMed Nätt D, Barchiesi R, Murad J, Feng J, Nestler EJ, Champagne FA, Thorsell A (2017). Perinatal Malnutrition Leads to Sexually Dimorphic Behavioral Responses with Associated Epigenetic Changes in the Mouse Brain. Sci Rep, 7(1):11082. PubMed