Dr. Michael Meredith
- Sensory physiology and brain circuits involved in chemosensory communication, including pheromones, studied by electrophysiological, anatomical and behavioral methods.
- Current Research
- We study female-to-male and male-to-male signaling in golden hamsters and mice as a model to analyze sensory mechanisms, in particular those leading to sensory control of behavior. Expression of immediate-early gene products such as Fos- and FRA-proteins (from the c-fos gene or related genes) are used as markers to indicate which neurons in the brain change activity under different conditions. Direct recording of neuronal electrical activity can also be used in some circumstances. Our primary interest is in understanding the principles of brain-circuit operation and not the development of therapies, but the unlearned recognition of chemosensory social signals that we study involves brain areas and circuits that have also been implicated in failures to recognize visual social signals, such as facial expressions, as in autism.
- Recent Publications
Westberry JM, Meredith M. (2016). GABAergic mechanisms contributing to categorical amygdala responses to chemosensory signals. Neuroscience, 186-96. PubMed Westberry JM, Meredith M. (2016). Characteristic response to chemosensory signals in GABAergic cells of medial amygdala is not driven by main olfactory input. Chem Senses., . PubMed Liu Y, Lieberwirth C, Jia X, Curtis JT, Meredith M, Wang ZX (2014). Chemosensory cues affect amygdaloid neurogenesis and alter behaviors in the socially monogamous prairie vole. Eur J Neurosci, 1632-41. PubMed Blake CB, Meredith M (2011). Change in number and activation of androgen receptor-immunoreactive cells in the medial amygdala in response to chemosensory input. Neuroscience, 228-38. PubMed Samuelsen CL, Meredith M (2011). Oxytocin antagonist disrupts male mouse medial amygdala response to chemical-communication signals. Neuroscience, 96-104. PubMed Blake CB, Meredith M (2010). Selective enhancement of main olfactory input to the medial amygdala by GnRH. Brain Res, 46-59. PubMed Moeller JF, Meredith M (2010). Differential co-localization with choline acetyl transferase in nervus terminalis suggests functional differences for GnRH isoforms in bonnethead sharks (Sphyrna tiburo). Brain Res, 44-53. PubMed Samuelsen CL, Meredith M (2009). The vomeronasal organ is required for the male mouse medial amygdala response to chemical-communication signals, as assessed by immediate early gene expression. Neuroscience, 1468-76. PubMed Samuelsen CL, Meredith M (2009). Categorization of biologically relevant chemical signals in the medial amygdala. Brain Res, 33-42. PubMed Nolte CM, Meredith M (2005). mGluR2 activation of medial amygdala input impairs vomeronasal organ-mediated behavior. Physiol Behav, 314-23. PubMed Meredith M, Westberry JM (2004). Distinctive responses in the medial amygdala to same-species and different-species pheromones. J Neurosci, 5719-25. PubMed Westberry J, Meredith M (2003). The influence of chemosensory input and gonadotropin releasing hormone on mating behavior circuits in male hamsters. Brain Res, 1-16. PubMed Meredith M (2001). Human vomeronasal organ function: a critical review of best and worst cases. Chem Senses, 433-45. PubMed