Debra Ann Fadool

Associate Professor

Ph.D., University of Florida & Whitney Laboratory, 1993
Olfactory Signal Transduction and Neuromodulation of Ion Channels

Biographical Sketch:

Education and Training (Click Here)

Laboratory Members:

Laboratory Homepage and Members (Click Here)

Overview of Research:

Click on the photographs to survey some of our current projects

Selected Publications:

  • Biju, K.C., Marks, D.R., T.G. Mast, and D.A. Fadool. 2008. Deletion of voltage-gated channel affects glomerular refinement and odor receptor expression in the olfactory system. J. Comp. Neurol. 506: 161-179. PDF ABSTRACT
  • Marks, D.R. and D.A. Fadool. 2007. Post-synaptic density 95 (PSD-95) affects insulin-induced Kv1.3 channel modulation of the olfactory bulb. J. Neurochem. 103(4): 1608-1627. PDF ABSTRACT
  • Colley, B.S., K.C. Biju, A. Visegrady, S. Campbell, and D.A. Fadool. 2007. TrkB increases Kv1.3 ion channel half-life and surface expression. Neuroscience 144(2):531-46. PDF ABSTRACT
  • Brann, J.H. and D.A. Fadool. 2006. Vomeronasal sensory neurons (VSNs) from Sternotherus odoratus (Stinkpot/Musk Turtle) respond to chemosignals via the phospholipase C (PLC) system. J. Exp. Biol. 209: 914-927 PDF ABSTRACT
  • Das, P., A.D. Parsons, J. Scarborough, J. Hoffman, J. Wilson, R.N. Thompson, J.M. Overton, and D.A. Fadool. 2005. Electrophysiological and behavioral phenotype of insulin receptor defective mice. Physiol. & Behav. 86(3):287-296.PDF ABSTRACT
  • Labra, A., J.H. Brann, and D.A. Fadool. 2005. Heterogeneity of voltage- and chemosignal-activated response profiles in vomeronasal sensory neurons. J. Neurophysiol. 94(4):2535-2548. PDF ABSTRACT
  • Fadool, D.A., K. Tucker, R. Perkins, G. Fasciani, R.N. Thompson, A.D. Parsons, J.M. Overton, P.A. Koni, R.A. Flavell, and L.K. Kaczmarek. 2004. Kv1.3 channel gene-targeted deletion produces "super-smeller mice" with altered glomeruli, interacting scaffolding proteins, and biophysics. Neuron 41(3): 389-404. PDF ABSTRACT
  • Colley, B., K. Tucker, D.A. Fadool. 2004. Comparison of modulation of Kv1.3 channel by two receptor tyrosine kinases in olfactory bulb neurons of rodents. Receptors & Channels 10: 1-12. PDF ABSTRACT
  • Wilkinson, B., J. Elam, D.A. Fadool, and R. Hyson. 2003. Afferent regulation of cytochrome-C and active caspase-9 in the avian cochlear nucleus. Neurosci. 120(4): 1071-1079. PDF ABSTRACT
  • Brann, J.H., J.C. Dennis, E.E. Morrison, and D.A. Fadool. 2002. Type-specific inositol 1,4,5-trisphosphate receptor localization in the vomeronasal organ and its interaction with a transient receptor potential channel, TRPC2. J. Neurochem. 83: 1-9.PDF ABSTRACT
  • Tucker, K. and D.A. Fadool. 2002. Neurotrophin modulation of voltage-gated potassium channels in rat through TrkB receptors is time and sensory-experience dependent. J. Physiol. 542.2: 413-429. PDF ABSTRACT
  • Cook, K.K. and D.A. Fadool. 2002. Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by Src kinase. J. Biol. Chem. 277: 13268-13280. PDF ABSTRACT
  • Fadool, D.A., Wachowiak, M., and J.H. Brann. 2001. Patch-clamp analysis of voltage-activated and chemically activated currents in the vomeronasal organ. J. Exp. Biol. 204: 4199-4212. PDF ABSTRACT
  • Murphy, F.A., K Tucker, and D.A. Fadool. 2001. Sexual dimorphism and developmental expression of signal transduction machinery in the vomeronasal organ. J. Comp. Neurol. 432: 61-74. PDF ABSTRACT
  • Fadool, D.A., K. Tucker, J.J. Philips, and J.A. Simmen. 2000. Brain insulin receptor causes activity-dependent current suppression in the olfactory bulb through multiple phosphorylation of Kv1.3. J. Neurophysiol. 83: 2332-2348. PDF ABSTRACT
  • Fadool, D.A. and I.B. Levitan. 1998. Modulation of olfactory bulb neuron potassium current by tyrosine phosphorylation. J. Neurosci. 18(16): 6126-6137. ABSTRACT
  • Holmes, T.C., D.A. Fadool, R. Ren, and I.B. Levitan. 1996. Direct association of src tyrosine kinase with the human Kv1.5 potassium channel mediated by src homology 3 domain. Science. 274: 2089-2091. ABSTRACT
  • Fadool, D.A. and B.W. Ache. 1994. Inositol 1,3,4,5-tetrakisphosphate (InsP4)-gated channels interact with inositol 1,4,5-trisphosphate (InsP3)-gated channels in olfactory receptor neurons. Proc. Natl. Acad. Sci. USA 91: 9471-9475. ABSTRACT
  • Fadool D.A. and B.W. Ache. 1992. Inositol 1,4,5-trisphosphate direct activation of channels in the plasma membrane of olfactory neurons. Neuron 9: 907-918. ABSTRACT
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