Dr. Nicolas  Thiebaud

KIN 3006
Florida State University
Department of Biological Science
Tallahassee, FL 32306-4295
(850) 645-3281

Principal Investigator
Dr. Debra A. Fadool

 Undergraduate
  Degree: Bachelor of Science
  Institution: University of Burgundy, Dijon, France
  Major: Cell Biology and Physiology
 Postgraduate
  Degree: Master of Science
  Institution: University of Burgundy, Dijon, France
  Major: Nutrition
  
  Degree: PhD
  Institution: University of Burgundy, Dijon, France
  Research Work: Characterization of Xenobiotic Metabolizing Enzymes in the rat olfactory mucosa: regulation and role in the peripheral detection of odorant molecules
  

Dr. Nicolas Thiebaud

 

Research Interest

I am particularly interested in the olfactory physiology. My present work focuses on studying and describing the relationships existing between olfactory bulb and general metabolism. Recently, I have been interested in the change of olfactory organization and electrophysiological properties associated with a metabolic imbalance consecutive to fat-enriched diets.

Abstracts

  • Thiebaud N, Llewellyn-Smith I, Gribble F, Reimann F, Trapp S, Fadool DA. Modulation of Mitral Cell Activity by Glucagon-like Peptide-1 is Conveyed by the Potassium Channel Kv1.3. 36th Congress of the Association for Chemoreception Sciences (AChemS), April 9-12, 2014 - Bonita Springs, Florida, USA.
  • Fadool DA, Thiebaud N, Cho S, Schwartz A, Mattousi H. Metabolic Sensing by the Olfactory Bulb. 36th Congress of the Association for Chemoreception Sciences (AChemS), April 9-12, 2014 - Bonita Springs, Florida, USA.
  • Thiebaud N, Fadool DA. Glucose and glucagon‐like peptide‐1 (GLP‐1) permit metabolic sensing by the olfactory system. UF/FSU Chemical. Senses Symposium, June 4th, 2013 - Gainesville, Florida, USA.
  • Thiebaud N, Llewellyn-Smith I, Gribble F, Reimann F, Trapp S, Fadool DA. Expression and Activity of Glucagon-like Peptide-1 in the Mouse Olfactory Bulb. 35th Congress of the Association for Chemoreception Sciences (AChemS), April 17-20, 2013 - Huntington Beach, California, USA.
  • Fadool DA, Al Koborssy D, Thiebaud N. Metabolic sensing by the olfactory bulb. 33rd Blankenese Conference, May 25-29, 2013 - Hamburg-Blankenese, Germany.
  • Thiebaud N, Johnson MC, Gale DS, Butler JL, Fadool DA. Hyperlipidemic diet induces apoptosis-dependent loss of olfactory sensory neurons and decreases olfactory acuity in mice. 42nd Society for Neuroscience (SfN) meeting, October 13-17, 2012 - New Orleans, Louisiana, USA.
  • Zahir HA, Gambon P, Thiebaud N, Fadool DA, Ochrietor JD. Characterization of Basigin and Monocarboxylate transporter gene expression in the mouse olfactory system. The American Society for Cell Biology (ASCB) meeting, December 15-19, 2012, San Francisco, California, USA.
  • Thiebaud N, Johnson MC, Gale DS, Butler JL, Fadool DA. High-fat diet causes loss of olfactory sensory neurons and their projections while concomitantly impairing olfactory learning and discrimination in mice. 17th International Symposium on Olfaction and Taste (ISOT), June 23-27, 2012 - Stockholm, SWEDEN.
  • Thiebaud N, Johnson MC, Gale AM, Fadool DA. High-fat diet or genetically-induced obesity reduces the number of olfactory sensory neurons and their axonal projections. 34th Congress of the AChemS, April 25-28, 2012 - Huntington Beach, California, USA.
  • Thiebaud N, Johnson MC, Fadool DA. Obesity-induced neuroanatomical changes in the mouse olfactory system. Guess speaker. March 17, 2012. University of West Georgia, Carrolton, USA.
  • Thiebaud N, Veloso S, Jakob I, Sicard G, Artur Y, Heydel JM and Le Bon AM. 2010. Olfactory xenobiotic metabolizing enzymes have an impact on the stimulating properties of some odorants. 32nd Congress of the Association for Chemoreception Sciences (AChemS), April 20-25, - St Pete Beach, USA.
  • Thiebaud N, Veloso S, Jakob I, Sicard G, Artur Y, Heydel JM and Le Bon AM. 2009. Inhibition of olfactory cytochrome P450-dependent activities modifies the electro-olfactogram responses to quinoline and coumarin in rats 19th Congress of the European Chemoreception Research Organisation (ECRO); September 24-27, Villasimius-Cagliari, ITALY.
  • Thiebaud N, Veloso S, Jakob I, Sicard G, Artur Y, Heydel JM and Le Bon AM. 2009. Biotransformation of odorants modifies the olfactory signal. 31st Congress of the AChemS, April 22-26, - Sarasota, FL, USA.
  • Thiebaud N, Sigoillot M, Chevalier J, Artur Y, Heydel JM and Le Bon AM. 2008. Activity and expression of drug metabolizing enzymes in olfactory mucosa of rats treated by hepatic inducers. 18th Congress of the ECRO; September 3-7, - Portoroz, SLOVENIA.

Selected Recent Publications

Thiebaud N, Johnson MC, Butler JL, Bell GA, Ferguson KL, Fadool AR, Fadool JC, Gale AM, Gale DS, Fadool DA. Hyperlipidemic diet causes loss of olfactory sensory neurons, reduces olfactory discrimination, and disrupts odor-reversal learning.. J. Neurosci.. 34(20):6970-84. (2014)
Tucker K, Cho S, Thiebaud N, Henderson M, Fadool DA. Glucose sensitivity of mouse olfactory bulb neurons is conveyed by a voltage-gated potassium channel.. J. Physiol.. 591(10): 2541-2561. (2013) PDF
Thiebaud N, Veloso Da Silva S, Jakob I, Sicard G, Chevalier J, Mntrier F, Berdeaux O, Artur Y, Heydel JM, Le Bon AM. Odorant Metabolism Catalyzed by Olfactory Mucosal Enzymes Influences Peripheral Olfactory Responses in Rats.. PLoS ONE. 8(3): e59547. (2013)
Tucker KR, Godbey SJ, Thiebaud N, Fadool DA. Olfactory ability and object memory in three mouse models of varying body weight, metabolic hormones, and adiposity.. Physiol. Behav.. 107(3): 424-432. (2012) PDF
Thiebaud N, Menetrier F, Belloir C, Minn AL, Neiers F, Artur Y, Le Bon AM, Heydel JM. Expression and differential localization of xenobiotic transporters in the rat olfactory neuro-epithelium.. Neurosci Lett. 505(2): 180-185. (2011)
Thiebaud N, Sigoillot M, Chevalier J, Artur Y, Heydel JM, Le Bon AM. Effects of typical inducers on olfactory xenobiotic metabolizing enzyme, transporter and transcription factor expression in rats. Drug Metab Dispos. 38:1865-1875. (2010)
Jean-Marie Heydel, Holsztynska EJ, Ariele Legendre, Thiebaud N, Yves Artur, Anne-Marie Le Bon. UDP-glucuronosyltransferases (UGTs) in neuro-olfactory tissues: expression, regulation, and function. Drug Metab Rev. 42:71-94. (2010)