Dr. Rohit Seth

G160 MSR
Florida State University
College of Medicine
1115 West Call Street
Tallahassee, FL 32306-4300
(850) 644-8025

Principal Investigator
Dr. Michael Overton

 2003
  Degree: Ph.D.
  Institution: Banaras Hindu University, Varanasi, India
  Major: Zoology
 1997
  Degree: M.S.
  Institution: Banaras Hindu University, Varanasi, India
  Major: Zoology
 1995
  Degree: B.S.
  Institution: Dr. Ram Manohar Lohiya Awadh University, Faizabad, India
  Major: (Biology) Zoology, Botany & Chemistry

Dr. Rohit Seth

Postdoctoral Associate

Ongoing research project

Presently working on topic "central neural control of energy balance, feeding behavior and cardiovascular function, obesity and hypertension". We are studying mechanisms by which reduced energy consumption produces marked reductions in blood pressure and sympathetic activity. We use chronically instrumented rats to assess cardiovascular status while manipulating caloric intake. CNS lesions and microinjection strategies are employed to evaluate specific neuroanatomic and neurochemical substrates which modulate blood pressure during negative energy balance.

Completed research project:

  1. Signal transduction in renal tubular epithelial cells in relation to cell death and cell survival pathways in caspase-3 knockouts. I worked as co-investigator in this project aimed to address the role of caspase in cisplatin induced acute renal failure. This project was supported by National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK), National Institutes of Health (Grant DK-58324) and an American Heart Association (Affiliated).
  2. p53 mediated caspase-2-activation in mitochondrial release of apoptosis inducing factor and its role in renal tubular epithelial cell injury. I worked as co-investigator in this project aimed to address the role of apoptosis inducing factor in cisplatin induced renal tubular epithelial cell injury. This project was supported by National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK), National Institutes of Health (Grant DK-58324) and an American Heart Association (Affiliate).

Publications

  • Dave Knight, Rohit Seth, Jim Boron, James Michael Overton. Short-term physiological hyperleptinemia decreases arterial blood pressure. Regulatory Peptide (2009) Apr 10;154(1-3):60-8.
  • Cheng Yang, Varsha Kaushal, Randy Haun, Rohit Seth, Sudhir V Shah and Gur P Kaushal. Transcriptional activation of caspase-6 and -7 genes by cisplatin-induced p53 and its functional significance in cisplatin nephrotoxicity. Cell Death Differ. (2008) Mar;15(3):530-44.
  • Christian Herzog, Rohit Seth, Sudhir V Shah and Gur P Kaushal. Role of meprin A in renal tubular epithelial cell injury. Kidney Int. (2007) May; 71(10): 1009-18.
  • Rohit Seth, Cheng Yang, Varsha Kaushal, Sudhir V Shah, and Gur P Kaushal. p53 mediated caspase-2-activation in mitochondrial release of apoptosis inducing factor and its role in renal tubular epithelial cell injury. Journal of Biological Chemistry (2005) Sep 2; 280(35): 31230-9.
  • Gur P Kaushal, Ling Liu, Varsha Kaushal, Xiaoman Hong, Oksana Melnyk, Rohit Seth, Robert Safirstein and Sudhir V Shah. Regulation of Caspase-3 and -9 Activation in Oxidant Stress to Renal Tubular Epithelial Cells By Forkhead proteins, Bcl-2 Proteins and MAP Kinases. American Journal of Physiology: Renal Physiology (2004). 287: F1258- F1268.
  • Rohit Seth, Yin Xue Xu, Roland Grossmann and Chandra Mohini Chaturvedi. Changes in Expression of AVT/ AVT receptor gene in hypothalamus and shell gland in relation to egg laying in white leghorn hens. General and Comparative Endocrinology. (2004) 137:177- 186.
  • Rohit Seth, Almut Köhler, Roland Grossmann and Chandra Mohini Chaturvedi. Expression of hypothalamic Arginine vasotocin gene in response to water deprivation and sex steroid administration in female Japanese quail. (2004) Journal of Experimental Biology 207: 3025-3033.
  • Rohit Seth, Roland Grossmann and Chandra Mohini Chaturvedi. In ovo administration of sex steroid alter vasotocin synthesis in bed nucleus of stria terminalis in chicken. Current Science. (August 2003) 85 (4): 497-502.
  • Rohit Seth and Chandra Mohini Chaturvedi. Age and sex dependent variation of arginine vasotocin gene in response to dehydration in chicken and Japanese quail. Zoological Studies. (2004) 43: (1) 86-92.
  • Roland Grossmann, Aleksandr Jurkevich, Almut Kohler, Rohit Seth, Yinxue Xu, Günther Marx, Sabine Klein, Lazlo Pal, Karoly Dublecz, Ruqian Zhao, Chen Jie and Ponchai Sanyathitiseree. Physiological Regulation of Adaptation Processes of Reproduction and Growth. Annual Report of Institute for Animal Science (2002): 68-69.
  • Rohit Seth and Chandra Mohini Chaturvedi. Beta agonist terbutalin supplementation induces lipolysis and protein synthesis in Japanese quail (Coturnix coturnix japonica). Indian Journal of Poultry Science. (August 2002) 37(2): 166-168.
  • Roland Grossmann, Aleksandr Jurkevich, Almut Kohler, Rohit Seth, Yinxue Xu, Günther Marx, Sabine Klein, Lazlo Pal, Karoly Dublecz, Ruqian Zhao, Chen Jie and Ponchai Sanyathitiseree. Physiological regulation of adaptation, reproduction and growth. Annual Report of Institute for Animal Science (2001): 68-69.

Awards and honors

  • Travel grant from American Society of Nephrology to attend 38th Annual Meeting of American Society of Nephrology, Philadelphia, Pennsylvania, USA November 8th 2005.
  • Senior Research Fellow (SRF), from CSIR (Council for Scientific and Industrial Research), New Delhi (2002).
  • DAAD fellowship, German academic exchange services (2001).
  • MP–SLET, Eligibility test for lectureship in Universities and Colleges across India (2001).
  • Junior Research Fellow (JRF) at Center of Advance Studies, Department of Zoology, BHU from University Grants Commission, New Delhi, India.
  • USDA (Indo-US fellowship), research grant FG-IN- (IN-ARS-866) to workn project: "Molecular biology of neuroendocrine system of poultry birds" (1999).
  • B.H.U. Fellow Merit in research entrance test (RET) of BHU (1998).
  • Best Oral Presentations at XIX th and XXI st Symposium of Society for Reproduction Biology and Comparative Endocrinology meeting (2001), Baroda, Gujarat and Varanasi UP (2003).

Academic Workshops:

  1. Radiation Safety Short Course. Department of Environmental Health and Safety Radiation Safety Office. Florida State University, Tallahassee, FL. February 6-20, 2007.
  2. Professional Development Seminar & Workshop (Early Career) during 38th Annual Meeting of American Society of Nephrology, Philadelphia, Pennsylvania, USA November 8th 2005.
  3. National Workshop on Multiphoton Confocal Microscopy, Cytogenetics laboratory, Dept. of Zoology, Banaras Hindu University, Varanasi (21- 26 Oct., 2002).
  4. Short term course on "Recent advances in reproductive endocrinology" and "Recent approaches on animal physiological research" at Indian Veterinary Research Institute (I.C.A.R), Izatnagar, Bareilly, (UP) India.
  5. Second and Third National Workshop on Biostatistics and Biometry (Oct. 31 - Nov. 4, 1996 & Dec. 25 - 30, 1998).

Abstracts / Proceedings

  1. William D Knight, Rohit Seth, James M Overton. Potent combination of amylin and leptin reduces food intake, blood pressure, and orexigenic neuropeptides in obese FBNF1 rats. Poster presentation at 16th annual meeting of the society for the study of ingestive behavior, July 2008, Paris.
  2. Michelina M Messina, Dawn E Kopa, William D Knight, Rohit Seth, and James M Overton. Acute low-dose I.P. Amylin+EB treatment in OVX rats does not produce an enhanced anorexigenic response. Poster presentation at 16th annual meeting of the society for the study of ingestive behavior, July 2008, Paris.
  3. Michelina M Messina, Rohit Seth, Lisa A Eckel, and James M Overton. Endogenous estradiol enhances, and ovariectomy suppresses, ERα- and cFos-immunoreactivity in the medial preoptic area. Poster presentation, Society for Neuroscience meeting, San Diego, CA, 2007
  4. William D Knight, Rohit Seth, and James M Overton. Peripheral leptin decreases arterial pressure and increases heart rate while maintaining fed-state metabolic rate during negative energy balance. Experimental Biology. Washington, DC. April 2007.
  5. Rohit Seth, William D Knight, and James M Overton. Re-feeding after long-term caloric restriction rapidly restores heart rate and metabolic rate but slowly restores body weight and incompletely restores serum leptin. Experimental Biology, Washington DC, USA April 2007.
  6. Rohit Seth., Yang, C., Shah S.V., and Kaushal, G.P. Harlequin mutant mice are protected against cisplatin induced nephrotoxicity. In 39th Annual Meeting of American Society of Nephrology, San Diego, CA, USA November 2006.
  7. Herzog, C., Rohit Seth, Shah, S.V., and Kaushal G.P. Meprin A is a novel mediator of proximal tubular epithelial cell injury in cisplatin nephrotoxicity – Protective role of meprin inhibitor actinonin. In 39th Annual Meeting of American Society of Nephrology, San Diego, CA, USA November 2006.
  8. Rohit Seth., Yang, C., Shah S.V., and Kaushal, G.P. p53 and caspase- dependent mitochondrial release of apoptosis-inducing factor (AIF) and its role in hypoxia/reoxygenation injury to renal tubular epithelial cells. In 38th Annual Meeting of American Society of Nephrology, Philadelphia, Pennsylvania, USA November 2005 Poster No. F- 0273.
  9. Yang, C., Kaushal, V., Rohit Seth, Shah, S.V., and Kaushal, G.P. Direct transactivation of inflammatory and ER-stress associated caspases by p53 and its role in cisplatin-induced acute renal failure. In 38th Annual Meeting of American Society of Nephrology, Philadelphia, Pennsylvania, USA November 2005 Poster No. SA- 0285.
  10. Rohit Seth., Yang, C., Shah, S.V., and Kaushal, G.P. Caspase-2- dependent and caspase-3-independent nuclear translocation of apoptosis- inducing factor and its role in renal tubular epithelial cell injury. [SU-PO821] In 37th Annual Meeting of American Society of Nephrology, St. Louis, Missouri, USA.
  11. Yang, C., Kaushal, V., Rohit Seth, Shah, S.V., and Kaushal, G.P [SU- PO826] Direct transcriptional up regulation by p53 of Caspase-6 and death-domain protein PIDD an activator of Caspase-2 in cisplatin injury to renal tubular epithelial cells. In 37th Annual Meeting of American Society of Nephrology, St. Louis, Missouri, USA.
  12. Rohit Seth, Xu, Y. X., Grossmann, R., and Chaturvedi C.M. (2002). Changes in expression of hypothalamic AVT/ AVT receptor gene in the hypothalamus and shell gland in relation to egg laying in white leghorn hen. In XXIst Conference of European Society of Comparative Endocrinologists, Aug. 26-30, 2002, page no. 168.
  13. Rohit Seth, Renu Bhatt., and Chaturvedi C.M. (2000). Gene expression of hypothalamic arginine vasotocin and oviposition in Japanese quail. In IVth congress of the Asia Oceania Society of Comparative Endocrinology, May 14-18, 2000. P-66. Page no. 73.
  14. Rohit Seth, Singh, S., Patel, S., and Chaturvedi C.M. (2000). Localization of AVT receptors in kidney and shell gland of osmotically stressed quail. In VIIth International symposium on Avian Endocrinology, Jan. 28 – Feb. 2, 2000, Department of Zoology, BHU, Varanasi, India. 8.08 (Poster).

Membership of Professional Societies

  • Life member, Society for Reproductive Biology and Comparative Endocrinology (SRBCE).
  • Member, American Physiological Society (APS).
  • Member, American Heart Association (AHA).
  • Council Member, Association of Scientists of Indian Origin in America (ASIOA)
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