Dr. Carlos A. Bolaños

B346 PDB
Florida State University
Department of Psychology
1107 W. Call Street
Tallahassee, FL 32306-4301
(850) 644-2627

Northeastern University

Bolaños Laboratory Home Page

Graduate Students
  Lyonna  Alcantara Lyonna Alcantara
(850) 645-4974

  Jacob  Brewer Jacob Brewer
A319 PDB
(850) 645-4974

  Eric  Parise Eric Parise
C370 PDB
(850) 645-4974

  Omar  Sial Omar Sial

(850) 644-3076

Dr. Carlos A. Bolaños

Associate Professor of Psychology & Neuroscience

Research Interest

  • Developmental Psychobiology
  • Animal Models of Neuropsychiatric Disorders
  • Neuropsychopharmacology
  • Signal Transduction

Current Research

Our research focuses on studying how exposure to antidepressants, stimulants, and other psychotropic drugs, as well as physical and emotional stress, leads to neurobiological adaptations of brain pathways involved in regulating reward, mood, and motivation in developmentally immature and adult animal models. We use a multilevel approach that involves behavioral, biochemical, and psychopharmacological analyses. In addition, we use in vivo gene transfer, using viral vectors, to regulate the expression of specific genes in discrete brain regions. The overall goal is to better understand ways in which the developing and adult brain responds to environmental, pharmacological and genetic manipulations resulting in pathological conditions.

Selected Recent Publications

Parise EM, Bolaños CA. Chronic Social Defeat and Intracranial Self-Stimulation: Unmasking the Many Faces of Depression?. Biol Psychiatry. 76(7): 513-514. (2014)
Iñiguez SD, Alcantara LF, Warren BL, Riggs LM, Parise EM, Vialou V, Wright KN, Dayrit G, Nieto SJ, Wilkinson MB, Lobo MK, Neve RL, Nestler EJ, Bolaños CA. Fluoxetine exposure during adolescence alters responses to aversive stimuli in adulthood.. J Neurosci. 34(3): 1007-1021. (2014)
Warren BL, Sial OK, Alcantara LF, Greenwood MA, Brewer JS, Rozofsky JP, Parise EM Bolaños CA. Altered gene expression and spine density in nucleus accumbens of adolescent and adult male mice exposed to emotional and physical stress.. Dev Neurosci.. 36(3-4): 250-260. (2014)
Alcantara LF, Warren BL, Parise EM, Iñiguez SD, Bolaños CA. Effects of psychotropic drugs on second messenger signaling and preference for nicotine in juvenile male mice.. Psychopharmacology. 231(8): 1479-1492. (2014)
Parise EM, Alcantara LF, Warren BL, Wright KN, Hadad R, Sial OK, Kroeck KG, Iñiguez SD, Bolaños CA. Repeated ketamine exposure induces an enduring resilient phenotype in adolescent and adult rats.. Biol Psychiatry. 74(10): 750-759. (2013)
Iñiguez SD, Charntikov S, Baella SA, Herbert MS, Bolaños-Guzmán CA, Crawford CA. Post-training cocaine exposure facilitates spatial memory consolidation in C57BL/6 mice. Hippocampus. in press. (2011)
Warren BL†, Iñiguez SD†, Alcantara LF, Wright KN, Parise EM, Weakley SK, Bolaños-Guzmán CA. Juvenile administration of concomitant methylphenidate and fluoxetine alters behavioral reactivity to reward- and mood-related stimuli and disrupts ventral tegmental area gene expression in adulthood. J Neurosci. 31(28): 10347-10358. (2011) [†Authors contributed equally to this work]
Iñiguez SD, Warren BL, Bolaños-Guzmán CA. Short- and Long-term Functional Consequences of Fluoxetine Exposure During Adolescence in Male rats. Biol Psychiatry. 67(11):1057-1066. (2010)
Iñiguez SD, Vialou V, Warren BL, Cao JL, Alcantara LF, Davis LC, Manojlovic Z, Neve RL, Russo SJ, Han MH, Nestler EJ, Bolaños-Guzmán CA. Extracellular Signal-Regulated Kinase-2 Within the Ventral Tegmental Area Regulates Responses to Stress. J Neurosci. 30(22):7652-7663. (2010)
Vialou V, Robison AJ, LaPlant QC, Covington III HE, Dietz DM, Ohnishi YN, Mouzon E, Rush III AJ, Watts EL, Wallace DL, Iñiguez SD, Ohnishi YH, Steiner MA, Warren BL, Krishnan V, Bolaños CA, Neve RL, Ghose S, Berton O, Tamminga CA, Nestler EJ. DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nat Neurosci. 13(6):745-752. (2010)
Laplant Q, Vialou V, Covington HE 3rd, Dumitriu D, Feng J, Warren BL, Maze I, Dietz DM, Watts EL, Iñiguez SD, Koo JW, Mouzon E, Renthal W, Hollis F, Wang H, Noonan MA, Ren Y, Eisch AJ, Bolaños CA, Kabbaj M, Xiao G, Neve RL, Hurd YL, Oosting RS, Fan G, Morrison JH, Nestler EJ. Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat Neurosci. 13(9), 1137-1143. (2010). (2010)
Russo SJ, Wilkinson MB, Mazei-Robison MS, Dietz DM, Maze I, Krishnan V, Renthal W, Graham A, Birnbaum SG, Green TA, Robison B, Lesselyong A, Perrotti LI, Bolaños CA, Kumar A, Clark MS, Neumaier JF, Bhakar AL, Barker PA, Nestler EJ. Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward. J Neurosci. 29(11):3529-37. (2009)
Wallace DL, Han MH, Graham DL, Green TA, Vialou V, Iñiguez SD, Cao JL, Kirk A, Chakravarty S, Kumar A, Krishnan V, Neve RL, Cooper DC, Bolaños CA, Barrot M, McClung CA, Nestler EJ. CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. Nat Neurosci. 12(2):200-9. (2009)
Graham DL, Krishnan V, Larson EB, Graham A, Edwards S, Bachtell RK, Simmons D, Gent LM, Berton O, Bolaños CA, DiLeone RJ, Parada LF, Nestler EJ, Self DW. Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Biol Psychiatry. 65(8):696-701. (2009)
Iñiguez SD†, Warren BL†, Parise EM, Alcantara LF, Schuh B, Maffeo ML, Manojlovic Z, Bolaños-Guzmán CA. Nicotine Exposure During Adolescence Induces a Depression-Like State in Adulthood. Neuropsychopharmacology. 34(6):1609-1620. (2009) [†Authors contributed equally to this work.]
Krishnan V, Han MH, Mazei-Robison M, Iñiguez SD, Ables JL, Vialou V, Berton O, Ghose S, Covington HE 3rd, Wiley MD, Henderson RP, Neve RL, Eisch AJ, Tamminga CA, Russo SJ, Bolaños CA, Nestler EJ. AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli. Biol Psychiatry. 64(8):691-700. (2008)
Bolaños CA, Willey MD, Maffeo ML, Powers KD, Kinka DW, Grausam KB, Henderson RP. Antidepressant treatment can normalize adult behavioral deficits induced by early-life exposure to methylphenidate. Biol Psychiatry. 63(3):309-16. (2008)
Wallace DL, Vialou V, Rios L, Carle-Florence TL, Chakravarty S, Kumar A, Graham DL, Green TA, Kirk A, Iñiguez SD, Perrotti LI, Barrot M, DiLeone RJ, Nestler EJ, Bolaños-Guzmán CA. The Influence of DeltaFosB in the Nucleus Accumbens on Natural Reward-Related Behavior. J Neurosci. 28(41):10272-10277. (2008)
Iñiguez SD, Warren BL, Neve RL, Nestler EJ, Russo SJ, Bolaños-Guzmán CA. Insulin Receptor Substrate-2 in the Ventral Tegmental Area Regulates Cocaine-Induced Behavioral Adaptations. Behav Neurosci. 122(5):1172-1177. (2008)
Russo SJ, Bolaños CA, Theobald DE, DeCarolis NA, Renthal W, Kumar A, Winstanley CA, Renthal NE, Wiley MD, Self DW, Russell DS, Neve RL, Eisch AJ, Nestler EJ. IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates. Nat Neurosci. 10(1):93-9. (2007)
Lagace DC, Yee JK, Bolaños CA, Eisch AJ. Biol Psychiatry. Juvenile administration of methylphenidate attenuates adult hippocampal neurogenesis. Biol Psychiatry. 60(10):1121-30. (2006)
Han MH, Bolaños CA, Green TA, Olson VG, Neve RL, Liu RJ, Aghajanian GK, Nestler EJ. Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors. J Neurosci. 26(17):4624-9. (2006)
Zachariou V, Bolaños CA, Selley DE, Theobald D, Cassidy MP, Kelz MB, Shaw-Lutchman T, Berton O, Sim-Selley LJ, Dileone RJ, Kumar A, Nestler EJ. An essential role for DeltaFosB in the nucleus accumbens in morphine action. Nat Neurosci. 9(2):205-11. (2006)
Olson VG, Zabetian CP, Bolaños CA, Edwards S, Barrot M, Eisch AJ, Hughes T, Self DW, Neve RL, Nestler EJ. Regulation of drug reward by cAMP response element-binding protein: evidence for two functionally distinct subregions of the ventral tegmental area. J Neurosci. 25(23):5553-62. (2005)
Perrotti LI, Bolaños CA, Choi KH, Russo SJ, Edwards S, Ulery PG, Wallace DL, Self DW, Nestler EJ, Barrot M. DeltaFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment. Eur J Neurosci. 21(10):2817-24. (2005)
Barrot M, Wallace DL, Bolaños CA, Graham DL, Perrotti LI, Neve RL, Chambliss H, Yin JC, Nestler EJ. Regulation of anxiety and initiation of sexual behavior by CREB in the nucleus accumbens. Proc Natl Acad Sci U S A. 102(23):8357-62. (2005)
Georgescu D, Sears RM, Hommel JD, Barrot M, Bolaños CA, Marsh DJ, Bednarek MA, Bibb JA, Maratos-Flier E, Nestler EJ, DiLeone RJ. he hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. J Neurosci. 25(11):2933-40. (2005)
Bolaños CA, Neve RL, Nestler EJ. Phospholipase C gamma in distinct regions of the ventral tegmental area differentially regulates morphine-induced locomotor activity. Synapse. 56(3):166-9. (2005)
Bolaños CA, Nestler EJ. Neurotrophic mechanisms in drug addiction. Neuromolecular Med. 5(1):69-83. (2004)
Alcantara LF, Iñiguez SD, Warren BL, Wright KN, Bolaños-Guzmán CA. Adolescent Administration of Combined Methylphenidate and Fluoxetine Treatment Results in a Long-lasting Alteration of Gene Expression within the Ventral Tegmental Area of C57BL/6 Mice. [In Preperation]